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Dr. G.N.Hendy

Jacques Mao

We thank Drs. Lilia D'Souza-Li and Svetlana Pidasheva, and Ruth Milkereit and Yaroslava Chtompei for their previous help with the database. We thank Drs. Lucie Canaff, Vito Guarnieri and Yves Sabbagh for revising and maintaining the present database.

Calcium Sensing Receptor Database

Amino acid sequence (1-1078) and key features of the human CASR: SP, signal peptide (1-19), yellow underlined box; ECD, extracellular domain (20-612); TMD, transmembrane domain (613-862); ICD, intracellular domain (862-1078). In the ECD: VFT, Venus flytrap domain, arrows indicate start (22) and end (528); Intramolecular disulfide bonds, cysteine (C) residues joined by lines; Functional N-linked glycosylation sites, filled arrowheads; Asterisks (*), leucine (L) residues and cysteine (C) residues contributing to hydrophobic and covalent intermolecular linkages, respectively, for dimer formation. In the TMD: transmembrane a-helices (TM1-TM7), bolded residues in orange boxes; intracellular loops (ICL1-ICL3); extracellular loops (ECL1-ECL3); disulfide bond between ECL2 and ECL3, cysteine (C) residues joined by a line. PKC sites, blue arrowheads (S or T) in TMD and ICD. (Hendy, G.N., Guarnieri, V., Canaff, L. Calcium-sensing receptor and associated diseases. Prog Mol Biol Transl Sci 2009;89C:31-95.)

Important Support
CIHR - Canadian Institutes of Health Research
The Canadian Genetic Diseases Network (CGDN-Network of Centers of Excellence)
Réseau de Médecine Génétique Appliquée (RMGA-FRSQ)
Robert McDonald Gift and Fund
Kidney Foundation of Canada
MRC of Canada (Group in Medical Genetics) (Historical)

43548 Hit(s)
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